Tudományos háttér

Matrix Metalloproteinase 3 (MMP-3) and Rheumatoid Arthritis

• Summary: MMP-3 has been identified as a critical biomarker in RA, playing a significant role in synovial inflammation and cartilage turnover. Elevated serum levels of MMP-3 correlate strongly with disease activity and radiographic progression in RA patients.

Baseline Serum MMP-3 Levels and Long-term RA Outcomes

• Summary: A longitudinal study found that baseline MMP-3 levels are strong predictors of radiographic progression in RA over an 8-year follow-up period. This highlights the potential of MMP-3 as a prognostic marker to anticipate disease outcomes and tailor therapeutic approaches.

MMP-3 as a Disease Activity Marker in RA

• Summary: Serum MMP-3 levels have shown significant correlation with disease activity in RA patients. This marker could help monitor the effectiveness of treatments, as reductions in MMP-3 levels are associated with clinical improvement.

Clinical Significance of Serum MMP-3 Measurement

• Summary: This study demonstrated that serum MMP-3 levels are significantly higher in RA patients compared to healthy controls and correlate with disease activity scores. Monitoring MMP-3 can assist in evaluating treatment responses, particularly with biologic therapies.